Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health


Author index

Page Path
HOME > Browse Articles > Author index
Kyung Yong Kim 1 Article
Acute Testis Toxicity of Bisphenol A Diglycidyl Ether in Sprague-Dawley Rats.
Yun Jung Yang, Shin Young Lee, Kyung Yong Kim, Yeon Pyo Hong
J Prev Med Public Health. 2010;43(2):131-137.
  • 5,841 View
  • 119 Download
  • 22 Crossref
AbstractAbstract PDF
Bisphenol A diglycidyl ether (BADGE) is a liquid compound obtained by condensation of two molecules of epichlorohydrin with one molecule of bisphenol A. General and reproductive toxicity with BADGE has been reported higher than 1000 mg/kg/day. This study was performed to show the effects of acute exposure to BADGE below 1000 mg/kg/day on the testis in adult male rats. METHODS: BADGE was administered by gastric lavage in a single dose of 500, 750, 1000, and 2000 mg/kg/day in 8-week old male SPF Sprague-Dawley rats. The right testis was processed for light microscopic analysis. The left testis was homogenized and spermatids were counted to determine the daily sperm production and daily abnormal sperm production. The sperm count, sperm motility, and incidence of abnormal sperm were estimated in the epididymis. In testicular sections, the seminiferous tubules were observed for qualitative changes. The progression of spermatogenesis was arbitrarily classified as full-matured, maturing, and immature. The specimen slide was observed at 3 points and 10 seminiferous tubules were evaluated at each point. RESULTS: The male rats exposed to single oral dose of BADGE at 750, 1000, and 2000 mg/kg/day were significantly increased the number of immature and maturing sperm on the testis. There were no significant differences with respect to sperm head count, sperm motility, and sperm abnormality in the BADGE treatment groups. CONCLUSIONS: These results suggest that single oral exposure of BADGE 750 mg/kg/day can affect adult male testis development.


Citations to this article as recorded by  
  • Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression
    Hesham A. El-Beshbishy, Dania S. Waggas, Rabab A. Ali
    Toxicon.2024; 241: 107674.     CrossRef
  • Subacute exposure to bisphenol F diglycidyl‐ether induces chronic dermatitis characterized by psoriasis‐like skin inflammation in mice
    Kyoko Kitagawa, Eiji Shibata, Megumi Yamamoto, Hiroshi Harada, Kiyoshi Yoshino, Toshihide Iwashita, Masanobu Oshima, Mayumi Tsuji
    Genes to Cells.2023; 28(1): 42.     CrossRef
  • N-Acetyl-L-Cysteine Ameliorates BPAF-Induced Porcine Sertoli Cell Apoptosis and Cell Cycle Arrest via Inhibiting the ROS Level
    Yue Feng, Junjing Wu, Runyu Lei, Yu Zhang, Mu Qiao, Jiawei Zhou, Zhong Xu, Zipeng Li, Hua Sun, Xianwen Peng, Shuqi Mei
    Toxics.2023; 11(11): 923.     CrossRef
  • A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE
    Dongqi Wang, Haoduo Zhao, Xunchang Fei, Shane Allen Synder, Mingliang Fang, Min Liu
    Environment International.2021; 155: 106701.     CrossRef
  • Impact of phthalates and bisphenols plasticizers on haemocyte immune function of aquatic invertebrates: A review on physiological, biochemical, and genomic aspects
    Mario Alberto Burgos-Aceves, Haitham G. Abo-Al-Ela, Caterina Faggio
    Journal of Hazardous Materials.2021; 419: 126426.     CrossRef
  • Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
    Alberto Ruiz Priego, Emilio González Parra, Sebastián Mas, José Luis Morgado-Pascual, Marta Ruiz-Ortega, Sandra Rayego-Mateos
    International Journal of Molecular Sciences.2021; 22(13): 7189.     CrossRef
  • Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances
    Shalenie P. den Braver-Sewradj, Rob van Spronsen, Ellen V. S. Hessel
    Critical Reviews in Toxicology.2020; 50(2): 128.     CrossRef
  • Importancia del bisfenol A, una toxina urémica de origen exógeno, en el paciente en hemodiálisis
    Sebastián Mas, Jesús Egido, Emilio González-Parra
    Nefrología.2017; 37(3): 229.     CrossRef
  • The importance of bisphenol A, an uraemic toxin from exogenous sources, in haemodialysis patients
    Sebastián Mas, Jesús Egido, Emilio González-Parra
    Nefrología (English Edition).2017; 37(3): 229.     CrossRef
  • Maternal Transfer of Bisphenol A During Nursing Causes Sperm Impairment in Male Offspring
    Ana Cristina Kalb, Ana Luiza Kalb, Tainã Figueiredo Cardoso, Cristina Gevehr Fernandes, Carine Dahl Corcini, Antonio Sergio Varela Junior, Pablo Elías Martínez
    Archives of Environmental Contamination and Toxicology.2016; 70(4): 793.     CrossRef
  • Occurrence of phthalate diesters (phthalates), p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE) and their derivatives in indoor dust from Vietnam: Implications for exposure
    Tri Manh Tran, Tu Binh Minh, Taha A. Kumosani, Kurunthachalam Kannan
    Chemosphere.2016; 144: 1553.     CrossRef
  • Novel Finding of Widespread Occurrence and Accumulation of Bisphenol A Diglycidyl Ethers (BADGEs) and Novolac Glycidyl Ethers (NOGEs) in Marine Mammals from the United States Coastal Waters
    Jingchuan Xue, Kurunthachalam Kannan
    Environmental Science & Technology.2016; 50(4): 1703.     CrossRef
  • The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood
    Enrique Bosch-Panadero, Sebastian Mas, Didier Sanchez-Ospina, Vanesa Camarero, Maria V. Pérez-Gómez, Isabel Saez-Calero, Pedro Abaigar, Alberto Ortiz, Jesus Egido, Emilio González-Parra
    Journal of the American Society of Nephrology.2016; 27(5): 1566.     CrossRef
  • Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species
    Ianina Hutler Wolkowicz, Gabriela V. Svartz, Carolina M. Aronzon, Christina Pérez Coll
    Environmental Toxicology and Chemistry.2016; 35(12): 3031.     CrossRef
  • Widespread Occurrence and Accumulation of Bisphenol A Diglycidyl Ether (BADGE), Bisphenol F Diglycidyl Ether (BFDGE) and Their Derivatives in Human Blood and Adipose Fat
    Lei Wang, Jingchuan Xue, Kurunthachalam Kannan
    Environmental Science & Technology.2015; 49(5): 3150.     CrossRef
  • Distribution of serum bisphenol A diglycidyl ether and its metabolite in Korean adult men and its association with reproductive hormone levels
    Sang-il Kim, Yun-jung Yang, Yeon-pyo Hong, Soon-Chul Myung, Sae-Chul Kim
    Molecular & Cellular Toxicology.2015; 11(1): 71.     CrossRef
  • Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece
    Alexandros G. Asimakopoulos, Nikolaos S. Thomaidis, Kurunthachalam Kannan
    Science of The Total Environment.2014; 470-471: 1243.     CrossRef
  • Bisphenol A in Chronic Kidney Disease
    Emilio González-Parra, Jose Antonio Herrero, Usama Elewa, Ricardo J. Bosch, Alberto Ortiz Arduán, Jesus Egido
    International Journal of Nephrology.2013; 2013: 1.     CrossRef
  • Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats
    Hesham A El-Beshbishy, Hamdy A A Aly, Mostafa El-Shafey
    Toxicology and Industrial Health.2013; 29(10): 875.     CrossRef
  • Silver nanoparticles effects on epididymal sperm in rats
    Joanna Gromadzka-Ostrowska, Katarzyna Dziendzikowska, Anna Lankoff, Małgorzata Dobrzyńska, Christine Instanes, Gunnar Brunborg, Aneta Gajowik, Joanna Radzikowska, Maria Wojewódzka, Marcin Kruszewski
    Toxicology Letters.2012; 214(3): 251.     CrossRef
  • Widespread Occurrence and Distribution of Bisphenol A Diglycidyl Ether (BADGE) and its Derivatives in Human Urine from the United States and China
    Lei Wang, Yinghong Wu, Wei Zhang, Kurunthachalam Kannan
    Environmental Science & Technology.2012; 46(23): 12968.     CrossRef
  • Effect of bisphenol A on the cauda epididymis of adult male albino rats and the possible protective role of quercetin
    Shireen A. Mazroa
    The Egyptian Journal of Histology.2011; 34(2): 377.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health