Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health


Author index

Page Path
HOME > Browse Articles > Author index
Kyung Dong Kim 1 Article
Reference Interval of Serum Thyroid Hormones in Healthy Korean Adults.
Yoon Young Jang, Chang Yoon Kim, Tae Yoon Hwang, Kyung Dong Kim, Chae Hoon Lee
J Prev Med Public Health. 2008;41(2):128-134.
  • 5,103 View
  • 60 Download
  • 12 Crossref
AbstractAbstract PDF
This study was conducted to determine the reference interval of serum thyroid hormones (TSH, FT(3), FT(4)) in healthy Korean adults. METHODS: Health examination data from 1,591 healthy Korean adults who visited an university hospital were analyzed. Patients with specific health conditions capable of altering laboratory results were excluded from the study. Serum thyroid hormones were measured using IMMULITE 2000 (DPC, USA, 2002). Subjects were 18-65 years old; 911 were male, and 690 were female. RESULTS: The arithmetic means of TSH, FT(3), and FT(4) values for male subjects were 1.28+/-1.84 micronIU/ml, 3.23+/-0.57 pg/ml, and 1.42+/-0.22 ng/dl, respectively. In female subjects, the arithmetic means of TSH, FT3, and FT4 values were 1.49+/-2.08 micronIU/ml, 3.08+/-0.54 pg/ml, and 1.29 +/-0.24 ng/dl, respectively. The arithmetic mean FT(4) value for males decreased with age (p<0.01). The arithmetic mean FT(3) value for females increased with age (p<0.01). The arithmetic mean thyroid hormone values of all study subjects differed significantly based on season. The arithmetic mean of male FT(4) decreased with increasing BMI (p<0.01). The arithmetic mean of female FT(3) increased with increasing BMI (p<0.01). The reference intervals recommended by the IMMULITE 2000 manufacturer are 0.40-4.00 micronIU/ml for TSH, 1.80-4.20 pg/ml for FT(3), and 0.80-1.90 ng/dl for FT(4) (same values for both genders). CONCLUSIONS: There was a significant difference in the interval of thyroid hormones between males and females, but the reference interval of IMMULITE 2000 was not established by gender. There is a need to reestablish the reference interval for thyroid hormones in Korean healthy adults.


Citations to this article as recorded by  
    Arijit Mazumdar
  • 2023 Korean Thyroid Association Management Guidelines for Patients with Subclinical Hypothyroidism
    Hyun Kyung Chung, Eu Jeong Ku, Won Sang Yoo, Yea Eun Kang, Kyeong Jin Kim, Bo Hyun Kim, Tae-Yong Kim, Young Joo Park, Chang Ho Ahn, Jee Hee Yoon, Eun Kyung Lee, Jong Min Lee, Eui Dal Jung, Jae Hoon Chung, Yun Jae Chung, Won Bae Kim, Ka Hee Yi, Ho-Cheol Ka
    International Journal of Thyroidology.2023; 16(1): 32.     CrossRef
  • Management of Subclinical Hypothyroidism: A Focus on Proven Health Effects in the 2023 Korean Thyroid Association Guidelines
    Eu Jeong Ku, Won Sang Yoo, Hyun Kyung Chung
    Endocrinology and Metabolism.2023; 38(4): 381.     CrossRef
  • A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?
    Alena Nikanorova, Nikolay Barashkov, Vera Pshennikova, Fedor Teryutin, Sergey Nakhodkin, Aisen Solovyev, Georgii Romanov, Tatiana Burtseva, Sardana Fedorova
    International Journal of Molecular Sciences.2023; 24(18): 14052.     CrossRef
  • Seasonal Fluctuations of Blood Pressure and Heart Rate in Healthy People: A Meta-Analysis of Panel Studies
    N. V. Kuzmenko, V. A. Tsyrlin, M. G. Pliss, M. M. Galagudza
    Human Physiology.2022; 48(3): 313.     CrossRef
  • Factors influencing the reference interval of thyroid‐stimulating hormone in healthy adults: A systematic review and meta‐analysis
    Dongyang Xing, Delong Liu, Ri Li, Qi Zhou, Jiancheng Xu
    Clinical Endocrinology.2021; 95(3): 378.     CrossRef
  • Seasonal variations in levels of human thyroid-stimulating hormone and thyroid hormones: a meta-analysis
    N. V. Kuzmenko, V. A. Tsyrlin, M. G. Pliss, M. M. Galagudza
    Chronobiology International.2021; 38(3): 301.     CrossRef
  • An exploratory study of the association between thyroid hormone and survival of amyotrophic lateral sclerosis
    Zhenzhen Zheng, Xiaoyan Guo, Rui Huang, Xueping Chen, Huifang Shang
    Neurological Sciences.2014; 35(7): 1103.     CrossRef
  • The Change of Thyroid Stimulating Hormone Values of Healthy Subjects According toTemperature and Aging
    Sung Su Kim, Dong Hoon Lew, Ja Yoon Choi, Eun Ju Lee, Min Gyo Kim, Kyong Young Kim, Soo Kyoung Kim, Jung Hwa Jung, Jae Hoon Jung, Jong Ryea l Hahm
    Kosin Medical Journal.2014; 29(2): 125.     CrossRef
  • Clinical implications of preoperative thyrotropin serum concentrations in patients who underwent thyroidectomy for nonfunctioning nodule(s)
    Dongju Kim, Jin-Woo Park
    Journal of the Korean Surgical Society.2013; 85(1): 15.     CrossRef
  • Serum thyrotropin as a risk factor for thyroid malignancy in euthyroid subjects with thyroid micronodule
    Seong‐Su Moon, Young‐Sil Lee, In‐Kyu Lee, Jung‐Guk Kim
    Head & Neck.2012; 34(7): 949.     CrossRef
  • Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome
    Yeo Kyung Lee, Jo Eun Kim, Hyun Ju Oh, Kyung Sun Park, Soo Kyung Kim, Seok Won Park, Moon Jong Kim, Yong Wook Cho
    The Korean Journal of Internal Medicine.2011; 26(4): 432.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health