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JPMPH : Journal of Preventive Medicine and Public Health

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Jung Wan Kim 3 Articles
Evaluation of Fourier Transform Near-infrared Spectrometer for Determination of Oxalate in Standard Urinary Solution.
Yeong Eun Kim, Su Hyung Hong, Jung Wan Kim, Jong Young Lee
J Prev Med Public Health. 2006;39(2):165-170.
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AbstractAbstract PDF
OBJECTIVES
The determination of oxalate in urine is required for the diagnosis and treatment of primary hyperoxaluria, idiopathic stone disease and various intestinal diseases. We examined the possibility of using Fourier transform near-infrared (FT-NIR) spectroscopy analysis to quantitate urinary oxalate. The practical advantages of this method include ease of the sample preparation and operation technique, the absence of sample pre-treatments, rapid determination and noninvasiveness. METHODS: The range of oxalate concentration in standard urine solutions was 0-221 mg/l. These 80 different samples were scanned in the region of 780-1,300 nm with a 0.5 nm data interval by a Spectrum One NTS FT-NIR spectrometer. PCR, PLSR and MLR regression models were used to calculate and evaluate the calibration equation. RESULTS: The PCR and PLSR calibration models were obtained from the spectral data and they are exactly same. The standard error of estimation (SEE) and the % variance were 10.34 mg/l and 97.86%, respectively. After full cross validation of this model, the standard error of estimation was 5.278 mg/l, which was much smaller than that of the pre-validation. Furthermore, the MCC (multiple correlation coefficient) was 0.998, which was compatible with the 0.923 or 0.999 obtained from the previous enzymatic methods. CONCLUSIONS: These results showed that FT-NIR spectroscopy can be used for rapid determination of the concentration of oxalate in human urine samples.
Summary
Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 Polymorphisms and the Risk of Gastric Cancer.
Su Hyung Hong, Jung Wan Kim, Ho Gak Kim, In Kyu Park, Jun Wook Ryoo, Chang Hyeong Lee, Yoon Kyung Sohn, Jong Young Lee
J Prev Med Public Health. 2006;39(2):135-140.
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  • 61 Download
AbstractAbstract PDF
OBJECTIVES
Polymorphisms of genes from glutathione Stransferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1 and GSTT1 null genotypes and NAT2 rapid acetylator type. Therefore, we investigated the association between the polymorphic types of GSTs (GSTM1, GSTT1, GSTP1) and NAT2 and the incidence of gastric cancer which is one of the most prevalent cancers among the East Asians. METHODS: It was performed in a case-control study consisting of 238 healthy subjects and 108 cancer patients (54 distal and 54 proximal carcinomas). We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location. RESULTS: In our study, the percentage of cases whose hometown was rural was higher than those of controls (odds ratio (OR) =2.88; 95% CI=1.72-4.76), and the frequency of the lower socio-economic status increased significantly in patients (OR=2.53; 95% CI=1.59-4.02). There was no significant difference in the GST polymorphic types between the cases and controls. However, NAT2 rapid or intermediate acetylator types were frequently detected in the cases with family history of gastric cancer (OR=1.92; 95% CI=1.79-26.0). CONCLUSIONS: These results suggest that the hometown and socio-economic status are important environmental factors for gastric carcinogenesis, and NAT2 polymorphic types could be associated with familial gastric carcinoma.
Summary
Survey on Fertility Rate and Family Planning in Sub-urban Area, Taegu.
Sung Kwan Lee, Kwan Yun Kim, Hae Kun Chung, Jung Wan Kim
Korean J Prev Med. 1975;8(1):53-69.
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AbstractAbstract PDF
It is very desirable to clarify the situation of fertility, family planning and attitude toward family size of the women residing in the sub-urban slum area because of underprivilege of socio-economiccondition of the residents and negligible health services (especially MCH and family planning) to the people in the area. The study area was selected a slum and primary fixation place of the people immigrated from rural area: Taegu, Dong Ku, Shin Chun Dong, 2 Ka and Taegu, Suh Ku, Ri San Dong, 1 Ka The survey was conducted by family planning workers at Health Center from December 1974 to February 1975. The results were obtained as follows: Thirty-eight percent of residents immigrated from rural area and most of there consist of nuclear family. Average monthly income per family was 38,000 won and 74 percent of them haven't their own houses. Number of pregnancy and live births per womon were 3.8 and 3.0 respectively. The rates of spontaneous and induced abortion to total married women were 9.5% and 36% respectively. Regarding delivery conditions, 86% of deliveries were performed at home and 70% of them were cared by non-professional person or without helpers. Ideal number of children account for 1.58 for sons, 1.08 for. daughters 2.655 for both, but the rate of 2 children regardless sex difference was only 3.4%. The factors influencing to family size were age and educational level of women and economic status of the hosehold. Regarding family planning, the rate of experience of contraception in the past was 48 percent while the rate of present contraception was 24%. Most frequent pregnancy order at the first contraception was 4th and most frequent age group of the women was 35-39 years in the past while the most frequent pregnancy order and the age of women were 3rd and 30-34 years at the first contraception in the present. Average fertility rate per year to total eligible women for 5 years 20.8% indicating somewhat higher than those of oter places. Age specific marital fertility rate showed higher in younger age groups than those of other places, and total fertility rate accounts for 1548.4 showing similar to rural total fertility rate in 1970 and higher than those of other urban areas.
Summary

JPMPH : Journal of Preventive Medicine and Public Health