Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Jooja Kim 1 Article
Increased DNA Damage of Lymphocytes in Korean Male Smokers.
Joohyun Lee, Eunil Lee, Eunha Oh, Juneyoung Lee, Donggeun Sul, Jooja Kim
J Prev Med Public Health. 2007;40(1):16-22.
DOI: https://doi.org/10.3961/jpmph.2007.40.1.16
  • 4,327 View
  • 35 Download
  • 2 Crossref
AbstractAbstract PDF
OBJECTIVE
The purpose of this study was to evaluate the levels of DNA damage in human lymphocytes caused by smoking and other lifestyle factors. METHODS: The study population consisted of 173 normal healthy male adults from 21 to 59 years old. The demographic and lifestyle variables were obtained from administered questionnaires. The level of lymphocytic DNA damage in the peripheral blood was evaluated by the Comet assay. Statistical analyses were done by general linear model analysis and Dunnett's multiple comparison. RESULTS: The difference in DNA damage between smokers and non-smokers was statistically significant. The means for the Tail%DNA were found to be 10.48 in the current smokers and 9.60 in the non-smokers (p<0.05). The tail moment means were 1.58 and 1.45 (p<0.05) for the current smokers and non-smokers, respectively. The number of cigarettes smoked per day did not result in a significant difference in the level of DNA damage among the smokers. Other lifestyle factors such as age, and drinking and exercise habits were not related to DNA damage. CONCLUSIONS: The DNA damage in the lymphocytes of smokers was found to be significantly higher than that for non-smokers. However, the number of cigarettes smoked per day was not related to DNA damage. Further study is needed to evaluate the relationship between the amount of smoking and level of damage to DNA. In addition, the status of DNA repair activities should be assessed.
Summary

Citations

Citations to this article as recorded by  
  • DNA strand breaks in peripheral blood leucocytes of Polish blood donors
    Małgorzata M Dobrzyńska, Krzysztof A Pachocki, Katarzyna Owczarska
    Mutagenesis.2018; 33(1): 69.     CrossRef
  • The effect of carrot juice, β-carotene supplementation on lymphocyte DNA damage, erythrocyte antioxidant enzymes and plasma lipid profiles in Korean smoker
    Hye-Jin Lee, Yoo Kyoung Park, Myung-Hee Kang
    Nutrition Research and Practice.2011; 5(6): 540.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health