- Species Differences in Effect of Ethanol to Urinary Metabolites Excretion of Trichloroethylene in Mice and Rats.
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Eun Yong Kang, Jung Duck Park, Yeon Pye Hong, Im Won Chang
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Korean J Prev Med. 1998;31(4):680-691.
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- This study was conducted to examine the species differences in the urinary excretion of trichloroethanol(TCE-OH) and trichloroacetic acid(TCA) of trichloroethylene(TCE) metabolites and the effect of ethanol on these metabolites in mice and rats. TCE administered to Male Sprague Dawley rats and ICR mice as a single oral dose(100, 200, 500, 1,000 or 2,000 mg/kg body weight) and ethanol(3.0 g/kg body weight) was taken orally 12 hours before TCE administration. The metabolites in urine were measured 0, 12, 24, 36 and 48 hours after TCE administration. The results of metabolite excretion were as follows; Total trichlorocompounds(TTC) in urine increased with TCE dose in mice while increased only below dose of 1,000 mg/kg TCE in rats. The net excretion of TCE metabolites was significantly greater in mice than rats, although the proportion of TCE-OH to TCA was not different between mice and rats. These findings indicate that mice were internally exposed to significantly higher concentration of TCE metabolites than rats and this trend appeared to be more prominent with the increase of TCE dose. Ethanol increased significantly TCE-OH in urine of rats while the increase of TCE-OH induced by ethanol was not significant in mice, and didn't increase TCA of urine in both of rats and mice. This result suggests that the effect of ethanol on TCE metabolism may be due to the increase of TCE-OH.
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Summary
- A Study on Urinary Cadmium Concentration and Renal Indices of Inhabitant in an Abandoned Mine Area.
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Jung Duck Park, Chan Byung Park, Byung Sun Choi, Eun Yong Kang, Yeon Pye Hong, Im Won Chang, Byung Yeol Chun, Min Hae Yeh
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Korean J Prev Med. 1998;31(3):424-439.
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- Urinary cadmium is used as a sensitive indicator for internal Cd dose, and increased excretion of N-acetyl-beta-D-glucosaminidase(NAG), beta(2)microglobulin(MG) and total protein are useful indices for renal dysfunction by chronic exposure to Cd. The target group was 184 inhabitant(82 men and 102 women) in an abandoned mine area known as exposure to low level Cd. The control group was took 160 individuals(64 men and 96 women) in Cd not-exposed area. Urinary Cd concentration was significantly higher in the target group than the control. The geometric mean of urinary Cd for male was 2.56ng/l, 2.80ng/g creatinine and 2.50ng/S.G. in the target group and 1.19ng/l, 1.36ng/g creatinine and 1.17ng/S.G. in the control. For female 2.69ng/l, 3.94ng/g creatinine and 2.63ng/S.G. in the target group and 1.27ng/l, 1.97ng/g creatinine and 1.25ng/S.G. in the control, respectively. In addition, urinary Cd of the target group had affected by the period of residence and dietary habit for the rice and the vegetables from the target area. These findings suggest the chronic exposure to Cd of the target population. Mean excretion of urinary NAG, beta(2)MG and total protein were not significant between two groups. In the target group, urinary NAG activity and total protein were significantly correlated with urinary Cd, but beta(2)MG was not related. Urinary excretion of NAG, beta(2)MG and total protein were significantly increased in 10 than in <2 of urinary Cd level. In 2~10 group of urinary Cd level, the excretion of NAG significantly increased while not showed for beta(2)MG. In present study, urinary excretion of NAG was relatively sensitive than beta(2)MG in chronic exposure population to low level Cd.
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- The Influence of Smoking and Alcohol Intake on Copper, Zinc, and Nitric Oxide Concentration in Serum.
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Yeon Pyo Hong, Byung Sun Choi, Jung Duci Park, Im Won Chang
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Korean J Prev Med. 1998;31(2):265-274.
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- To investigate the change of nitric oxide(No), copper, and zinc in serum on smoking and alcohol ingestion in young adults, this study was performed in a cross-sectional study in 127 healthy, men in Korea who had HBsAg(-), HCVAb(-), and no symptomatic liver, heart, gastrointestinal, chronic diseases, and inflammatory sign(lower than 10,000 white blood cell count in CBC). At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of NO, copper, and zinc. Each man completed a questionnaire that provided information on smoking, alcohol intake and present and past medical history. NO was analyzed by HPLC(Green et al., 1982), copper and zinc by atomic absorption spectrophotometer with air-acetylene flame and total cholesterol(TC) by Spectrum EPX. smoking(number of cigarettes per day and pack-year) and alcohol intake was grouped tertile. Copper was adjusted for age and zinc and for age and TC. NO, copper, and zinc on smoking and alcohol ingestion were analyzed in general linear models, respectively. NO, copper and zinc in serum did not show statistical differences between non-smoking and high-smoking group and no-alcohol intake and high-alcohol intake group. This study, suggested that copper, zinc, and NO was not good biological marker for early effect by smoking and alcohol intake in young adults. However, selection bias should be Considered in evaluation of this result. A large prospective study, will be needed in advance on usefulness of copper, zinc, and NO as a marker for risk fictors and early change of atherosclerosis.
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Summary
- Normal Predicted Values of Pulmonary Function of the Primary School Children in Rural Area and Sensitive Index of Respiratory Symptoms.
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Byung Sun Choi, Jung Duck Park, Yeon Pyo Hong, Im Won Chang
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Korean J Prev Med. 1995;28(3):690-705.
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- Pulmonary function tests were conducted on 815 healthy primary school children (390 males and 425 female) in rural area using Collins Survey Spirometer (warren E. collins, Inc, U. S. A.) with X-Y Recorder. Respiratory symptoms(cough, sputum, sore throat, chest pain, chest tightness, dyspnea, coryza) were surveyed by the interviews. Multiple regression analysis and regression diagnostics were done for prediction equations of FVC, FEV1, PEFR and FEF25-75% . FVC, FEV1, PEFR and FEF25-75% values in 3 groups of children classified by the number of symptom were compared each other through standard variable value. FVC, FEV1, PEFR and FEF25-75% showed highly significant correlation with age, height and weight. Prediction equations for FVC, FEV1, PEER, FEF25-75% are functions of height only in both male and female children aged between 6 and 12 years old. PEFR showed a significant difference related with the number of symptom in female. These results suggest that the PEFR is sensitive PFT parameter in this study.
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Summary
- Induction Of Metallothionein And Toxicity In Acute Cadmium Intoxicated Rat.
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Kyung Joon Min, Jung Duck Park, Yeon Pyo Hong, Im Won Chang
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Korean J Prev Med. 1993;26(2):231-250.
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- Thirty five male Sprague-Dawley rats were treated with cadmium chloride solution ranging from 0.2 to 3.2mg CdCl2/kg by intravenous single injection. At 48 hours after administration of cadmium, total cadmium, MT bound cadmium and histopathologic finding in liver, kidney, lung, heart, testis, metallothionein in liver, kidney and total cadmium in blood were examined. Tissue cadmium concentration was highest in liver, followed by in kidney, heart, lung and testis. Cadmium bound to metallothionein(MT-Cd) and ratio of MT-Cd to total cadmium were increased in liver and kidney dependently of cadmium exposure dose, but not significantly changed in other organs. On histopathologic finding, the most susceptible organ was heart in considering cadmium exposed dose, but testis in considering cadmium concentration. Blood cadmium concentration was increased with dose-dependent pattern, and significantly correlated with tissue cadmium concentration, so that we may estimate tissue cadmium concentration by measurement of blood cadmium concentration. Metallothionein in liver and kidney was increased with dose-dependent pattern, higher in liver than in kidney, and was significantly correlated with tissue cadmium concentration. However, metallothionein induction efficiency of tissue cadmium(microgram MT/microgram Cd) was greater in liver than in kidney, and reverse to tissue concentration or exposed dose of cadmium.
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Summary
- Effect of the non-Medical Services on Attitude to Hospital Utilization.
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Hyun Kyung Lee, Im Won Chang
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Korean J Prev Med. 1988;21(2):442-450.
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- Effects of various factors related to the process of social action of hospital services on the selecting a hospital were investigated by using of questionnaires answered by 1,319 patients in a certain University Hospital, in Chungchongnam-Do, from November, 1986 to November, 1987. The results summarized were as follows ; 1. Each of the examined factors, that is, sincerity of an attendant physician in medical treatment and explaining the condition of a disease, confidence to doctor and nurse, doctor's and nurse's response to calling by patient, kindness of the hospital staffs and food handlers, sanitariness of hospital, cleanness of clothes and bed sheets, hospital foods, and rest surroundings, are not solely decisive to attitude of hospital utilization, but the factors effects compositely on hospital utilization. 2. Hospital services of the social action process are more effective to hospital utilization in cases of the hospitalization caused by the traffic facility than for the medical skill and facilities.
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- Study on the Attitude to Home Attendants System and Home Nursing Education of the Housewives in the City.
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Ki Jung Kim, Im Won Chang
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Korean J Prev Med. 1988;21(2):380-389.
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- This study was conducted in order to find out the attitude of housewives toward the home attendants system, the type of institute managing home attendants, the education for home attendants, the basic requisites for home attendants, and home nursing education, and identify the factors influencing on the housewives's attitude. The data were collected through questionnaires obtained from 401 housewives from March 1 to March 31, 1988. The results summarized were as follows; 1) 90.2 percent of total housewives favored the home attendants system, and housewives who had have their family member with health problem especially showed favorable response. 2) The favored types of institution managing home attendants appeared to be private social work agency(33.0%), half-private and half-public agency(32.2%), government agency(19.9%) and profit agency(2.2%). In particular, housewives who had experienced nursing favored half-private and half-public agency(37.6%). 3) As the basic requisites for home attendants, housewives wanted service attitude(37.2%), nursing education(34.4%) and nursing experience(28.4%). But, housewives with nursing experience favored nursing education rather than service attitude. 4) 91.1% of total housewives favored the home nursing education. In particular, housewives of high education level and nursing experience showed more favorable response to the home nursing education.
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- Effect of Menopause on the Mental Health of Climacteric Women.
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Wan Kyoon Shin, Im Won Chang
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Korean J Prev Med. 1985;18(1):157-171.
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- An attemption was made to estimate the effect of menopause on the mental health of climacteric women. The Minnesota Multiphasic Personality Inventory(MMPI) were questioned to 278 premenopausal women and 302 postmenopausal women. Data were analyzed by one-way analysis of variance in each variable of menopause, age, educational level, religion and partnership of husband, and two-way analysis of variance in two variables of menopause and one of other variables. The results were summarized as follows. 1. Menopause increased the scores of validity, psychopathic deviate, hypomania and paranoia scale, but conversely decreased the score of masculinity-femininity scale. 2. The older the climacteric women were, the lower scores of masculinity-femininity scale were observed. 3. The older the premenopausal women were, the higher scores of depression, hysteria, psychopathic deviate, psychasthenia and schizophrenia scale were observed, on the contrary, all scores of the postmenopausal women were decreased by the increment of their ages. 4. The higher the educational level of climacteric women were, the higher scores of correction and masculinity-femininity scale were observed, but the scores of hypochondriasis, hysteria, schizophrenia and social introversion scale were decreased by the increment of their educational level. 5. The scores of hypomania scale were higher in women of Buddhism than other religions. 6. The scores of validity, paranoia, psychasthenia, schizophrenia and social introversion scale were higher in windows than women with husband.
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Summary
- Analysis of Health Conditions Influencing on Industrial Accidents by Cornell Medical Index.
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Im Won Chang
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Korean J Prev Med. 1979;12(1):31-37.
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- By evaluating the health status of 152 male workers engaged in a metal-product factory by Cornell Medical Index in conjunction with their experience of industrial accident, I attempted to find out whether any health condition may effect on the occurrence of industrial accident. Differences in frequency of complaints in each section of CMI between control workers and accident workers were statistically tested by T-test. On the other hand, influence of neuropsychiatric factors (section M-R) on the occurrence of accidents was analyzed by X(2)-test with Fukamachi's classification. The followings were the results obtained in this study. 1. The average number (26.42) of physical complaints in accident group is significantly more than in control group (18.70). 2. The average number (17.70) of mental complaints in accident group is very significantly more than in control group (11.70). 3. Differences in frequencies of complaints by sections between accident group and control group was all significant except C(cardiovascular system), H(genitourinary system), I (fatigue) & J (frequency of disease). 4. Frequency rate of neurotic workers who were identified by Fukamachi's classification was significantly higher in accident group (72%) than in control group (51%).
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Summary
- Health Status in Urban Slum Area.
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Im Won Chang, Kyu Chull Chung
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Korean J Prev Med. 1977;10(1):3-15.
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- In order to find out health problems among inhabitants in slum areas in Kwanak-Ku, Seoul, a series of health survey was conducted upon 510 households by interview from March to December, 1976. The results obtained were as follows: 1. Employments of householders were unstable; Out of 508 householders, 164(32.3%) were unemployed and 184(36.2%) were daily or temporary employees. 2. Average number of households per house was 2.0 and average area of residential room per person was 4.0m2. 3. 476(93.3%) out of 510 households were supplied with tap water and rest of them made use of ground water as a source of drinking water. 4. Only 279(18.3%) out of 1527 live births were delivered at medical facilities, 496(32.7%) were at home attended by doctors or midwives and 358(25.1%) took prenatal care. The above findings were worse in urban slum area than in other urban area of relatively high economic level, but were better than in rural area of less medical facilities. 5. Initiation of treatment were delayed until their illnesses were advanced in most of the households, 472(92.5%) out 510. In the early stage of the illness, 131(25.6%) of the households sought physicians in their clinics or general hospitals and 250(40.9%) visited chemists, to buy drugs at first hand. Frequency of visits to physician increased to 52.8% as the disease aggravated in later stages. 6. Cost of medical expenditure per household amounted to 815 won, and was paid to, in the order of chemists, physicians, chinese herb stores, chinese herb doctors. 7. Concerning the health knowledge of the inhabitants, 273(53.9%) out of 506 respondents were aware of the infectivity of pulmonary tuberculosis, and 68(13.4%) of them checked regularly their chest findings by X-ray at least once every two years. 8. As for the family planning, although 448(87.3%) out of 510 respondents were in favor of it, 213(41.8%) of them were actually practicing contraception. 9. About 40.6% (125 respondents) of them obtained information and knowledge concerning contraception through personal contact with family planning workers. 10. Nutritional status of housewives was generally poor: 49(38.3%) out of 128 housewives were found to be anemic and average serum protein level was 7.5+/-0.82 g/dl.
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