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Dong-Yoon Kang 1 Article
Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients
Dong-Yoon Kang, Soyoung Park, Chul-Woo Rhee, Ye-Jee Kim, Nam-Kyong Choi, Joongyub Lee, Byung-Joo Park
J Prev Med Public Health. 2012;45(4):219-226.   Published online July 31, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.4.219
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AbstractAbstract PDF
Objectives

To evaluate the risk of fractures related with zolpidem in elderly insomnia patients.

Methods

Health claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set the hazard period of 1 day length prior to the fracture date and four control periods of the same length at 5, 10, 15, and 20 weeks prior to the fracture date. Time independent confounding factors such as age, gender, lifestyle, cognitive function level, mobility, socioeconomic status, residential environment, and comorbidity could be controlled using the casecrossover design. Time dependent confounding factors, especially co-medication of patients during the study period, were adjusted by conditional logistic regression analysis. The odds ratios and their 95% confidence intervals (CIs) were estimated for the risk of fracture related to zolpidem.

Results

One thousand five hundred and eight cases of fracture were detected in insomnia patients during the study period. In our data, the use of zolpidem increased the risk of fracture significantly (adjusted odds ratio [aOR], 1.72; 95% CI, 1.37 to 2.16). However, the association between benzodiazepine hypnotics and the risk of fracture was not statistically significant (aOR, 1.00; 95% CI, 0.83 to 1.21). Likewise, the results were not statistically significant in stratified analysis with each benzodiazepine generic subgroup.

Conclusions

Zolpidem could increase the risk of fracture in elderly insomnia patients. Therefore zolpidem should be prescribed carefully and the elderly should be provided with sufficient patient education.

Summary

Citations

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    Chong Xu, Janice Ching Nam Leung, Jiaying Shi, Dawn Hei Lum, Francisco Tsz Tsun Lai
    Sleep Medicine Reviews.2024; 73: 101866.     CrossRef
  • Burden of narcolepsy in Japan: A health claims database study evaluating direct medical costs and comorbidities
    Yuta Kamada, Aya Imanishi, Shih-Wei Chiu, Takuhiro Yamaguchi
    Sleep Medicine.2024; 114: 119.     CrossRef
  • Analysis of Drugs Prescribed to Elderly Patients in a Tertiary Health Care Center in Raipur, Central India: An Observational Study
    Yogendra Keche, Nitin R Gaikwad, Preetam N Wasnik, Keshao Nagpure, Md Sabah Siddiqui, Apoorva Joshi, Suryaprakash Dhaneria, Gevesh Dewangan, Jhasaketan Meher, Pranita Das
    Cureus.2024;[Epub]     CrossRef
  • Professionals' treatment goals for long-term benzodiazepine and Z-drugs management: a qualitative study
    Pauline Van Ngoc, Melissa Ceuterick, Jean-Luc Belche, Beatrice Scholtes
    BJGP Open.2024; 8(1): BJGPO.2023.0034.     CrossRef
  • Nurses' attitudes, beliefs and knowledge of sleep health in residential aged care: An integrative literature review
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    Journal of Advanced Nursing.2024;[Epub]     CrossRef
  • Reasons and impacts of hypnotic overuse in seniors
    Petra Höferová, Eva Aigelová
    Psychiatrie pro praxi.2024; 25(3): E1.     CrossRef
  • Comparative risk of fracture in community‐dwelling older adults initiating suvorexant versus Z‐drugs: Results from LIFE study
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    Journal of the American Geriatrics Society.2023; 71(1): 109.     CrossRef
  • Analysis of the prescription trends of potentially inappropriate medications in Korean older outpatients by sex: A retrospective study using data from the health insurance review and assessment service
    Jae-Yong Dong, Jin-Han Ju, Young-Mo Yang
    Medicine.2023; 102(34): e34818.     CrossRef
  • Effectiveness of suvorexant versus benzodiazepine receptor agonist sleep drugs in reducing the risk of hip fracture: Findings from a regional population-based cohort study
    Ryozo Yoshioka, Seiichiro Yamamoto, Eiji Nakatani, Norio Yasui-Furukori
    PLOS ONE.2023; 18(4): e0284726.     CrossRef
  • The epidemiology of new persistent hypnotic/sedative use after surgical procedures: a retrospective cohort study
    D. H. Magnusson, T. I. Albertsson, F. Jonsdottir, M. I. Sigurdsson
    Anaesthesia.2023; 78(8): 995.     CrossRef
  • Zolpidem as a high risk factor for elderly suicide in South Korea
    Eun Kim, Jae Hee Lee, Duk Hee Lee
    Archives of Suicide Research.2022; 26(2): 831.     CrossRef
  • Reducing Sedative-Hypnotics Among Hospitalized Patients: a Multi-centered Study
    Christine Soong, Cheryl Ethier, Yuna Lee, Dalia Othman, Lisa Burry, Peter E. Wu, Karen A. Ng, John Matelski, Barbara Liu
    Journal of General Internal Medicine.2022; 37(10): 2345.     CrossRef
  • Very long-term outcome of cognitive behavioral therapy for insomnia: one- and ten-year follow-up of a randomized controlled trial
    Susanna Jernelöv, Kerstin Blom, Nils Hentati Isacsson, Pontus Bjurner, Ann Rosén, Martin Kraepelien, Erik Forsell, Viktor Kaldo
    Cognitive Behaviour Therapy.2022; 51(1): 72.     CrossRef
  • Efficacy and safety of Z-substances in the management of insomnia in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing
    Vincenz Scharner, Lukas Hasieber, Andreas Sönnichsen, Eva Mann
    BMC Geriatrics.2022;[Epub]     CrossRef
  • Insomnia Diagnosis, Prescribed Hypnotic Medication Use, and Risk for Serious Fall Injuries in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
    S Justin Thomas, Swati Sakhuja, Lisandro D Colantonio, Mei Li, Paul Muntner, Kristi Reynolds, C Barrett Bowling
    Sleep.2022;[Epub]     CrossRef
  • Potentially Inappropriate Medication Use in Patients with Dementia
    Kyungwon Yoon, Jung-Tae Kim, Won-Gun Kwack, Donghyun Kim, Kyung-Tae Lee, Seungwon Yang, Sangmin Lee, Yeo-Jin Choi, Eun-Kyoung Chung
    International Journal of Environmental Research and Public Health.2022; 19(18): 11426.     CrossRef
  • Z-drugs and falls in nursing home patients: data from the INCUR study
    Sarah Damanti, Moreno Tresoldi, Philipe de Souto Barreto, Yves Rolland, Matteo Cesari
    Aging Clinical and Experimental Research.2022; 34(12): 3145.     CrossRef
  • Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial
    Ingo Fietze, Claudio L. A. Bassetti, David W. Mayleben, Scott Pain, Dalma Seboek Kinter, William V. McCall
    Drugs & Aging.2022; 39(10): 795.     CrossRef
  • Reacciones adversas medicamentosas de los hipnóticos más utilizados en España
    A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-del Castillo
    Revista Clínica Española.2021; 221(2): 128.     CrossRef
  • Adverse drug reactions among the most used hypnotic drugs in Spain
    A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-Del Castillo
    Revista Clínica Española (English Edition).2021; 221(2): 128.     CrossRef
  • Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies
    Kathryn Richardson, George M Savva, Penelope J Boyd, Clare Aldus, Ian Maidment, Eduwin Pakpahan, Yoon K Loke, Antony Arthur, Nicholas Steel, Clive Ballard, Robert Howard, Chris Fox
    Health Technology Assessment.2021; 25(1): 1.     CrossRef
  • Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person
    Christine E. Mc Carthy
    Medical Sciences.2021; 9(2): 31.     CrossRef
  • Effectiveness of App-Based Yoga of Immortals (YOI) Intervention for Insomnia in Asian Population during Pandemic Restrictions
    Renuka Tunuguntla, Hari Siva Gurunadha Rao Tunuguntla, Himanshu Kathuria, Sadhna Verma
    International Journal of Environmental Research and Public Health.2021; 18(11): 5706.     CrossRef
  • Effects of anticholinergic and sedative medication use on fractures: A self‐controlled design study
    Shahar Shmuel, Virginia Pate, Marc J. Pepin, Janine C. Bailey, Yvonne M. Golightly, Laura C. Hanson, Til Stürmer, Rebecca B. Naumann, Danijela Gnjidic, Jennifer L. Lund
    Journal of the American Geriatrics Society.2021; 69(11): 3212.     CrossRef
  • Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study
    Garu A, Shozo Yano, Abdullah Md Sheik, Aorigele Yu, Kenta Okuyama, Miwako Takeda, Kunie Kohno, Masayuki Yamasaki, Minoru Isomura, Toru Nabika, Atsushi Nagai
    Journal of Clinical Medicine.2021; 10(15): 3225.     CrossRef
  • Clinical consequences of abuse and misuse of hypnotics and analgesics in geriatric population
    Paulina Trawka, Jakub Husejko, Kornelia Kędziora-Kornatowska
    BÓL.2021; 22(2): 1.     CrossRef
  • Exploring the Mechanisms Underlying Drug-Induced Fractures Using the Japanese Adverse Drug Event Reporting Database
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    Pharmaceuticals.2021; 14(12): 1299.     CrossRef
  • Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review
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    European Journal of Clinical Pharmacology.2020; 76(3): 363.     CrossRef
  • Association between benzodiazepines use and risk of hip fracture in the elderly people: A meta-analysis of observational studies
    Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
    Joint Bone Spine.2020; 87(3): 241.     CrossRef
  • Association entre prise de benzodiazépines et risque de fracture de la hanche chez la personne âgée : méta-analyse d’études observationnelles
    Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
    Revue du Rhumatisme.2020; 87(3): 210.     CrossRef
  • Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial
    Thomas C Neylan, Anne Richards, Thomas J Metzler, Leslie M Ruoff, Jonathan Varbel, Aoife O’Donovan, Melinda Sivasubramanian, Terri Motraghi, Jennifer Hlavin, Steven L Batki, Sabra S Inslicht, Kristin Samuelson, Stephen R Morairty, Thomas S Kilduff
    Sleep.2020;[Epub]     CrossRef
  • More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults
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    Experimental Gerontology.2020; 136: 110962.     CrossRef
  • Association of Hypnotic Drug Use with Fall Incidents in Hospitalized Elderly Patients: A Case-Crossover Study
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    Biological and Pharmaceutical Bulletin.2020; 43(6): 925.     CrossRef
  • Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer’s Disease
    Shanna L. Burke, Tianyan Hu, Christine E. Spadola, Aaron Burgess, Tan Li, Tamara Cadet
    Journal of Aging and Health.2019; 31(2): 322.     CrossRef
  • Twelve-year trend in the use of zolpidem and physicians’ non-compliance with recommended duration: a Korean national health insurance database study
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    European Journal of Clinical Pharmacology.2019; 75(1): 109.     CrossRef
  • Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies
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  • Effectiveness and safety of fire-needle moxibustion on insomnia
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    Medicine.2019; 98(7): e14509.     CrossRef
  • Treatment of sleep disturbance in older adults
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  • An Implementation Guide to Promote Sleep and Reduce Sedative-Hypnotic Initiation for Noncritically Ill Inpatients
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    JAMA Internal Medicine.2019; 179(7): 965.     CrossRef
  • Evaluation of Dissolution Profile between Original and Generic Products of Zolpidem Tartrate by Microdialysis-HPLC
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  • Insomnia, Benzodiazepine Use, and Falls among Residents in Long-term Care Facilities
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  • Association Between Sleep Medications and Falls and Fall-related Worries in Community-Dwelling Older Adults in the United States
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  • Z-drugs and risk for falls and fractures in older adults—a systematic review and meta-analysis
    Nir Treves, Amichai Perlman, Lital Kolenberg Geron, Angham Asaly, Ilan Matok
    Age and Ageing.2018; 47(2): 201.     CrossRef
  • Age, Sex, and Dose Effects of Nonbenzodiazepine Hypnotics on Hip Fracture in Nursing Home Residents
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  • Cognitive Enhancers Associated with Decreased Risk of Injury in Patients with Dementia: A Nationwide Cohort Study in Taiwan
    Pei-Chun Chao, Wu-Chien Chien, Chi-Hsiang Chung, Ching-Wen Chu, Chin-Bin Yeh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Nian-Sheng Tzeng
    Journal of Investigative Medicine.2018; 66(3): 684.     CrossRef
  • Insomnia in Elderly Patients: Recommendations for Pharmacological Management
    Vivien C. Abad, Christian Guilleminault
    Drugs & Aging.2018; 35(9): 791.     CrossRef
  • Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications
    Shanna L. Burke, Tianyan Hu, Christine E. Spadola, Tan Li, Mitra Naseh, Aaron Burgess, Tamara Cadet
    Sleep Medicine.2018; 52: 168.     CrossRef
  • An effectiveness comparison of acupuncture treatments for insomnia disorder
    Jing Chen, Liming Lu, Nenggui Xu, Jun Chen, Yupeng Fan, Fen Feng, Xiaolan Qin, Yu Kui
    Medicine.2018; 97(35): e12060.     CrossRef
  • Zolpidem-Induced Acute Altered Level of Consciousness: A Report of Two Cases
    Abdolhamid Parsa, Seyyed Ali Tabaeian, Sadra Einizadeh, Mohammad Babaeian
    Iranian Journal of Psychiatry and Behavioral Sciences.2018;[Epub]     CrossRef
  • Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
    Daniel F. Kripke
    F1000Research.2018; 5: 918.     CrossRef
  • Effects of Ramelteon and Other Sleep-Promoting Drugs on Serum Low-Density Lipoprotein and Non-high-density Lipoprotein Cholesterol: A Retrospective Comparative Pilot Study
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    Biological and Pharmaceutical Bulletin.2018; 41(12): 1778.     CrossRef
  • Zopiclone Use and Risk of Fractures in Older People: Population-Based Study
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  • Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
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  • Benzodiazepines, Z-drugs and the risk of hip fracture: A systematic review and meta-analysis
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  • Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research
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  • A Greater Extent of Insomnia Symptoms and Physician-Recommended Sleep Medication Use Predict Fall Risk in Community-Dwelling Older Adults
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  • High Prevalence of Inappropriate Benzodiazepine and Sedative Hypnotic Prescriptions among Hospitalized Older Adults
    Elisabeth Anna Pek, Andrew Remfry, Ciara Pendrith, Chris Fan‐Lun, R. Sacha Bhatia, Christine Soong
    Journal of Hospital Medicine.2017; 12(5): 310.     CrossRef
  • Zolpidem use and risk of fractures: a systematic review and meta-analysis
    S. M. Park, J. Ryu, D. R. Lee, D. Shin, J. M. Yun, J. Lee
    Osteoporosis International.2016; 27(10): 2935.     CrossRef
  • Melatonin, hypnotics and their association with fracture: a matched cohort study
    Martin Frisher, Nicholas Gibbons, James Bashford, Steve Chapman, Scott Weich
    Age and Ageing.2016; 45(6): 801.     CrossRef
  • Characteristics and Trends in Hypnotics Consumption in the Largest Health Care System in Israel
    O. Marom, G. Rennert, N. Stein, K. Landsman, G. Pillar
    Sleep Disorders.2016; 2016: 1.     CrossRef
  • Screening Tool for Older Persons’ Appropriate Prescriptions for Japanese: Report of the Japan Geriatrics Society Working Group on “Guidelines for medical treatment and its safety in the elderly”
    Taro Kojima, Katsuyoshi Mizukami, Naoki Tomita, Hiroyuki Arai, Takashi Ohrui, Masato Eto, Yasushi Takeya, Yoshitaka Isaka, Hiromi Rakugi, Noriko Sudo, Hidenori Arai, Hiroaki Aoki, Shigeo Horie, Shinya Ishii, Koh Iwasaki, Shin Takayama, Yusuke Suzuki, Tosh
    Geriatrics & Gerontology International.2016; 16(9): 983.     CrossRef
  • Review of Safety and Efficacy of Sleep Medicines in Older Adults
    Jennifer L. Schroeck, James Ford, Erin L. Conway, Kari E. Kurtzhalts, Megan E. Gee, Krista A. Vollmer, Kari A. Mergenhagen
    Clinical Therapeutics.2016; 38(11): 2340.     CrossRef
  • Nonbenzodiazepine Sedative Hypnotics and Risk of Fall-Related Injury
    Sarah E. Tom, Emerson M. Wickwire, Yujin Park, Jennifer S. Albrecht
    Sleep.2016; 39(5): 1009.     CrossRef
  • Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
    Daniel F. Kripke
    F1000Research.2016; 5: 918.     CrossRef
  • Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam
    Cheng-Fang Yen, Chih-Hung Ko, Yu-Ping Chang, Cheng-Ying Yu, Mei-Feng Huang, Yi-Chun Yeh, Jin-Jia Lin, Cheng-Sheng Chen
    Asia-Pacific Psychiatry.2015; 7(3): 298.     CrossRef
  • An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population
    Hsin-I Shih, Che-Chen Lin, Yi-Fang Tu, Chia-Ming Chang, Hsiang-Chin Hsu, Chih-Hsien Chi, Chia-Hung Kao
    Medicine.2015; 94(17): e809.     CrossRef
  • The Use of Hypnotics to Treat Sleep Problems in the Elderly
    Catherine McCall, John W. Winkelman
    Psychiatric Annals.2015;[Epub]     CrossRef
  • Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics
    Chia-Ling Lin, Mei-Chang Yeh, Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
    Medicine.2015; 94(38): e1621.     CrossRef
  • Care Needs and Clinical Outcomes of Older People with Dementia: A Population-Based Propensity Score-Matched Cohort Study
    Fei-Yuan Hsiao, Li-Ning Peng, Yu-Wen Wen, Chih-Kuang Liang, Pei-Ning Wang, Liang-Kung Chen, Alessandra Marengoni
    PLOS ONE.2015; 10(5): e0124973.     CrossRef
  • Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan
    Yih-Jing Tang, Shinn-Ying Ho, Fang-Ying Chu, Hung-An Chen, Yun-Ju Yin, Hua-Chin Lee, William Cheng-Chung Chu, Hui-Wen Yeh, Wei-Shan Chiang, Chia-Lun Yeh, Hui-Ling Huang, Nian-Sheng Tzeng, Uwe Rudolph
    PLOS ONE.2015; 10(12): e0146030.     CrossRef
  • Evaluation of risk factors for fractures in postmenopausal women with osteoporosis
    Viktória Ferencz, Csaba Horváth, Sándor Huszár, Katalin Bors
    Orvosi Hetilap.2015; 156(4): 146.     CrossRef
  • Association between use of benzodiazepines and risk of fractures: a meta-analysis
    D. Xing, X. L. Ma, J. X. Ma, J. Wang, Y. Yang, Y. Chen
    Osteoporosis International.2014; 25(1): 105.     CrossRef
  • Non-benzodiazepine hypnotics and older adults: what are we learning about zolpidem?
    Hedva B Levy
    Expert Review of Clinical Pharmacology.2014; 7(1): 5.     CrossRef
  • Long-Term Use of Zolpidem Increases the Risk of Major Injury: A Population-Based Cohort Study
    Ming-May Lai, Cheng-Chieh Lin, Che-Chen Lin, Chiu-Shong Liu, Tsai-Chung Li, Chia-Hung Kao
    Mayo Clinic Proceedings.2014; 89(5): 589.     CrossRef
  • Risk of hip fracture among older people using anxiolytic and hypnotic drugs: a nationwide prospective cohort study
    Marit Stordal Bakken, Anders Engeland, Lars B. Engesæter, Anette Hylen Ranhoff, Steinar Hunskaar, Sabine Ruths
    European Journal of Clinical Pharmacology.2014; 70(7): 873.     CrossRef
  • Treatment of Insomnia in Older Adults: Re-Evaluating the Benefits and Risks of Sedative Hypnotic Agents
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    Journal of Gerontological Nursing.2013; 39(4): 48.     CrossRef
  • In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving
    Naren Gunja
    Journal of Medical Toxicology.2013; 9(2): 163.     CrossRef
  • Ten-year trend in prescriptions of z-hypnotics among the elderly: A nationwide, cross-sectional study in Taiwan
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    Journal of Clinical Gerontology and Geriatrics.2013; 4(2): 37.     CrossRef
  • Zolpidem, Is it a Safe Drug for Insomnia Management?
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