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David R Jacobs 2 Articles
Interaction Between Persistent Organic Pollutants and C-reactive Protein in Estimating Insulin Resistance Among Non-diabetic Adults
Ki-Su Kim, Nam-Soo Hong, David R Jacobs, Duk-Hee Lee
J Prev Med Public Health. 2012;45(2):62-69.   Published online March 31, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.2.62
  • 10,036 View
  • 82 Download
  • 12 Crossref
AbstractAbstract PDF
Objectives

Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes. Based on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects.

Methods

Cross-sectional associations among serum POPs, C-reactive protein (CRP), and homeostasis model assessment of insulin resistance (HOMA-IR) were investigated in 748 non-diabetic participants aged ≥20 years. Nineteen types of POPs in 5 subclasses were selected because the POPs were detectable in ≥60% of the participants.

Results

Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations. There were statistically significant interactions between CRP and OC pesticides and between CRP and PCBs, in estimating HOMA-IR (P for interaction <0.01 and <0.01, respectively). CRP was not associated with HOMA-IR among subjects with low concentrations of OC pesticides or PCBs, while CRP was strongly associated with HOMA-IR among subjects with high concentrations of these POPs.

Conclusions

In the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance.

Summary

Citations

Citations to this article as recorded by  
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  • The associations between endocrine disrupting chemicals and markers of inflammation and immune responses: A systematic review and meta-analysis
    Zhiqin Liu, Yao Lu, Kunxia Zhong, Chenchen Wang, Xi Xu
    Ecotoxicology and Environmental Safety.2022; 234: 113382.     CrossRef
  • Endocrine Disruptors and the Induction of Insulin Resistance
    Rafael Vanni, Renata Maksoud Bussuan, Renato Luiz Rombaldi, Alberto K. Arbex
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  • Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies
    F.M. Peinado, F. Artacho-Cordón, R. Barrios-Rodríguez, J.P. Arrebola
    Environmental Research.2020; 186: 109561.     CrossRef
  • Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals
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  • Health and environmental effects of persistent organic pollutants
    Omar M.L. Alharbi, Al Arsh Basheer, Rafat A. Khattab, Imran Ali
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  • The influence of persistent organic pollutants in the traditional Inuit diet on markers of inflammation
    L. K. Schæbel, E. C. Bonefeld-Jørgensen, H. Vestergaard, S. Andersen, Jaymie Meliker
    PLOS ONE.2017; 12(5): e0177781.     CrossRef
  • Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study
    Martha P. Montgomery, Eric Postel, David M. Umbach, Marie Richards, Mary Watson, Aaron Blair, Honglei Chen, Dale P. Sandler, Silke Schmidt, Freya Kamel
    Environmental Health Perspectives.2017;[Epub]     CrossRef
  • Hemostatic, inflammatory, and oxidative markers in pesticide user farmers
    Fatima Zohra Madani, Merzouk Hafida, Sid Ahmed Merzouk, Bouchra Loukidi, Katia Taouli, Michel Narce
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    Mary Turyk, Giamila Fantuzzi, Victoria Persky, Sally Freels, Anissa Lambertino, Maria Pini, Davina H. Rhodes, Henry A. Anderson
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  • Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland
    L. K. Schæbel, E. C. Bonefeld-Jørgensen, P. Laurberg, H. Vestergaard, S. Andersen
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  • Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort
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Relationship Between Serum Concentrations of Organochlorine Pesticides and Metabolic Syndrome Among Non-Diabetic Adults.
Sun Kyun Park, Hyo Kyung Son, Sung Kook Lee, Jung Ho Kang, Yoon Seok Chang, David R Jacobs, Duk Hee Lee
J Prev Med Public Health. 2010;43(1):1-8.
DOI: https://doi.org/10.3961/jpmph.2010.43.1.1
  • 5,814 View
  • 134 Download
  • 42 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes. METHODS: Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected. RESULTS: After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (beta-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of beta-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (> or =100 mg/dL)) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01). CONCLUSIONS: Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.
Summary

Citations

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  • Cross-sectional associations of persistent organic pollutants measured in adipose tissue and metabolic syndrome in clinically diagnosed middle-aged adults
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    Environmental Research.2023; 222: 115350.     CrossRef
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  • Pesticides and insulin resistance-related metabolic diseases: Evidences and mechanisms
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  • Health risk assessment of exposure to organochlorine pesticides in the general population in Seoul, Korea over 12 years: A cross-sectional epidemiological study
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    Journal of Hazardous Materials.2022; 424: 127381.     CrossRef
  • Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)
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    International Journal of Environmental Research and Public Health.2022; 19(6): 3344.     CrossRef
  • Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case–Control Study Among the North-Indian Population
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  • Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
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    Environmental Pollution.2022; 305: 119288.     CrossRef
  • Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System
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  • Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
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    FEBS Letters.2022; 596(24): 3107.     CrossRef
  • Gene expression in rat placenta after exposure to di(2-ethylhexyl) phthalate
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  • Umweltgifte und ihre hormonelle Wirkung
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  • The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis
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    Scientific Reports.2021;[Epub]     CrossRef
  • Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects
    Elsi Haverinen, Mariana F. Fernandez, Vicente Mustieles, Hanna Tolonen
    International Journal of Environmental Research and Public Health.2021; 18(24): 13047.     CrossRef
  • Smokeless tobacco use: its prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso
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    BMC Public Health.2020;[Epub]     CrossRef
  • Persistent Organic Pollutant-Mediated Insulin Resistance
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  • Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals
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  • “Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells”
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  • Effects on the reproductive parameters of two generations ofRattus norvegicusoffspring from dams exposed to heptachlor during gestation and lactation
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  • Mixture effects of 30 environmental contaminants on incident metabolic syndrome—A prospective study
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  • Association of persistent organic pollutants and non-persistent pesticides with diabetes and diabetes-related health outcomes in Asia: A systematic review
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    Environment International.2015; 76: 57.     CrossRef
  • Endokrin wirkende Umweltgifte
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  • Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites
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    PLOS ONE.2015; 10(12): e0143190.     CrossRef
  • Umweltgifte und ihre hormonelle Wirkung
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  • Prospective associations between persistent organic pollutants and metabolic syndrome: A nested case–control study
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    Science of The Total Environment.2014; 496: 219.     CrossRef
  • Association of Persistent Organic Pollutants (POPs) with Age and Body Mass Index in Korean Adults
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  • Perinatal Exposure to Low-Dose Methoxychlor Impairs Testicular Development in C57BL/6 Mice
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  • Can persistent organic pollutants and plastic‐associated chemicals cause cardiovascular disease?
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  • Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels
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  • Endocrine Disruptors: From Endocrine to Metabolic Disruption
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  • Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat
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    American Journal of Physiology-Endocrinology and Metabolism.2011; 301(3): E527.     CrossRef

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