- Association between the Pattern of Prophylactic Antibiotic Use and Surgical Site Infection Rate for Major Surgeries in Korea.
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Pilyong Sakong, Jin Seok Lee, Eun Jung Lee, Kwang Pil Ko, Cheol Hwan Kim, Yoon Kim, Yong Ik Kim
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J Prev Med Public Health. 2009;42(1):12-20.
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DOI: https://doi.org/10.3961/jpmph.2009.42.1.12
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 Abstract
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- OBJECTIVES
The purpose of this study was to analyze the association between the pattern of prophylactic antibiotic use (PAU) and the surgical site infection (SSI) rate for major surgeries in Korea. METHODS: We retrospectively reviewed the medical records of patients who underwent cardiac, colon and gastric surgery, hysterectomies and hip/knee replacements at 20 hospitals, and inclusive of over 500 beds. We randomly sampled 60 cases per surgery type for patients discharged between September and November, 2006. A total fo 2,924 cases were included in our analysis. Cox's proportional hazard analysis was conducted to evaluate the association between the pattern of PAU and SSI rate. RESULTS: The proportion of patients who received their first prophylactic antibiotics (PA) 1 hour before incision was 65.5%, who received inappropriate PAs was 80.8%, and the proportion of patients whose PA was discontinued within 24 hours of surgery was 0.5%. The average duration of PAU after surgery was 9 days. The relative risk (RR) of SSI in patients who received their first PA more than 1 hour before incision was significantly higher than for those who received it within 1 hour prior to incision (RR=8.20, 95% CI=4.81-13.99). Inappropriate PA selection increased SSI rate, albeit with marginal significance (RR=1.97, 95% CI=0.96-4.03). Also, prolonged PAU following surgery had no effect on SSI rate. CONCLUSIONS: These results suggest that the pattern of PAU in the surgeries examined was not appropriate. Errors in the timing of PAU and of PA selection increase SSI rate. SSI rate remained unaltered following prolonged PAU after surgery.
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Summary
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Citations
Citations to this article as recorded by  - The effect of first- and third-generation prophylactic antibiotics on hospitalization and medical expenditures for cardiac surgery
Sung-Jin Bae, Inah Kim, Jaechul Song, Euy-Suk Chung
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Dae-Geun Kim, Byung Hoon Kwack
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Mi Young Jung, Kyung-Yeon Park
Journal of Korean Academy of Fundamentals of Nursing.2018; 25(4): 240. CrossRef - Comparing the Postoperative Complications, Hospitalization Days and Treatment Expenses Depending on the Administration of Postoperative Prophylactic Antibiotics to Hysterectomy
Mi Young Jung, Kyung-Yeon Park
Korean Journal of Women Health Nursing.2017; 23(1): 42. CrossRef - Factors affecting the rate of antibiotic prescription in dental practices
Hyesung Kim, Myeng Ki Kim, Hyungkil Choi
Journal of Korean Academy of Oral Health.2017; 41(1): 28. CrossRef - Convergence Research on Periodic Changes in the Quality Assessment of Surgical Prophylactic Antibiotics
Sae-Yie Yang, Kwang-Hwan Kim
Journal of Digital Convergence.2016; 14(6): 325. CrossRef - Risk Factors for Surgical Site Infections According to Electronic Medical Records Data
Young Hee Kim, Young-Hee Yom
Journal of Korean Academy of Fundamentals of Nursing.2014; 21(2): 151. CrossRef - Appropriateness of Surgical Antibiotic Prophylaxis in a Tertiary Hospital
Eun Young Nam, Hong Bin Kim, Hyunok Bae, Soyoung Moon, Sun Hee Na, Se Yong Kim, Doran Yoon, Ha Youn Lee, Joohae Kim, Chung-Jong Kim, Kyoung-Ho Song, Eu Suk Kim, Nam Joong Kim
Korean Journal of Nosocomial Infection Control.2014; 19(2): 64. CrossRef - Incidence and Risk Factors for Surgical Site Infection after Gastric Surgery: A Multicenter Prospective Cohort Study
Su Jin Jeong, Hea Won Ann, Jae Kyung Kim, Heun Choi, Chang Oh Kim, Sang Hoon Han, Jun Yong Choi, Kyong Ran Peck, Cheol-In Kang, Joon-Sup Yeom, Young Hwa Choi, Seung-Kwan Lim, Young Goo Song, Hee Jung Choi, Hee Jung Yoon, Hyo-Youl Kim, Young-Keun Kim, Min
Infection & Chemotherapy.2013; 45(4): 422. CrossRef - Overview of Antibiotic Use in Korea
Baek-Nam Kim
Infection & Chemotherapy.2012; 44(4): 250. CrossRef - The epidemiology and cost of surgical site infections in Korea: a systematic review
Kil Yeon Lee, Kristina Coleman, Dan Paech, Sarah Norris, Jonathan T Tan
Journal of the Korean Surgical Society.2011; 81(5): 295. CrossRef - A Prospective Study of Single-Dose Antibiotic Prophylaxis in Live Donor Nephrectomy
Ho Sung Jang, Kyung Hwa Choi, Seung Choul Yang, Woong Kyu Han
Korean Journal of Urology.2011; 52(2): 115. CrossRef - Association Between Prophylactic Antibiotic Use and Surgical Site Infection Based on Quality Assessment Data in Korea
Kyoung Hoon Kim, Choon Seon Park, Jin Hee Chang, Nam Soon Kim, Jin Seo Lee, Bo Ram Choi, Byung Ran Lee, Kyoo Duck Lee, Sun Min Kim, Seon A Yeom
Journal of Preventive Medicine and Public Health.2010; 43(3): 235. CrossRef - Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day
Han Deok Kwak, Dong Jin Choi, Si Uk Woo, Jin Kim, Jun Won Um, Seon Hahn Kim
Journal of the Korean Surgical Society.2010; 78(6): 385. CrossRef - A Prospective, Multicenter, Randomized Trial for Duration of the Prophylactic Antibiotics after Elective Colorectal Surgery: 3 Days versus 5 Days
Ji Won Park, Jae Hwan Oh, Hyo Seong Choi, Sang-Bum Yoo, Young-Ju Choe, Sohee Park, Jung Man Kim, Kang Young Lee, Seung Kook Sohn, Hae Ran Yun, Ho-Kyung Chun, Woo Yong Lee
Journal of the Korean Society of Coloproctology.2010; 26(2): 123. CrossRef
- Mortality among Medical Doctors Based on the Registered Cause of Death in Korea 1992-2002.
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You Cheol Shin, Jae Heon Kang, Cheol Hwan Kim
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J Prev Med Public Health. 2005;38(1):38-44.
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Abstract
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- OBJECTIVE
To compare the mortality rate of Korean medical doctors to that of the general Korean population for the period 1992-2002. METHODS: The membership records of the Korean Medical Association were linked to the 1992-2002 death certificate data of Korea's National Statistical Office using 13-digit unique personal identification numbers. The study population consisted of 61, 164 medical doctors with a follow-up period of 473, 932 person-years. Standardized mortality ratios (SMRs) were calculated to compare cause-specific mortality rates of medical doctors to those of the general population. RESULTS: We confirmed 1, 150 deaths at ages from 30 to 75 years from 1 January 1992 to 31 December 2002. The SMR for all-cause of death was 0.47 (95% CI : 0.44~0.50). The SMRs for smoking-related diseases such as cerebrovascular accidents and chronic obstructive pulmonary disease were smaller than the SMR of all-cause of death. However, the SMRs for colorectal and pancreatic cancers were not significantly lower than those of the general population. Transport accidents and suicides accounted for 72% (94 of 131) of external causes of death. The SMR for suicide was 0.51 (95% CI : 0.38~0.68). CONCLUSIONS: The mortality rate of South Korean medical doctors was less than 50% that of the general population of South Korea. Cause-specific analysis showed that mortality rates in leading causes of death were lower among medical doctors although differences in mortality rates between medical doctors and the general population varied with the causes of death. These health benefits found among medical doctors may be attributable to the lower level of health damaging behaviors (e.g., lower smoking rates) and better working conditions.
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Summary
- A Telephone Survey on the Opinions about Family Doctor.
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Hong Gwan Seo, Jae Heon Kang, Cheol Hwan Kim, Seong Won Kim
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Korean J Prev Med. 1998;31(2):310-322.
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- In order to reinforce the role of primary care physician and to improve doctor-patient relationship, the Korean government tried to introduce 'Family Doctor Registration Program' into Seocho-Gu in Seoul, Ansung-Gun and Paju city in Kyunggi-Do in Oct. 1996. Community residents and doctors in those area did not show much interest in this project because of low incentives. We have done this study to see how much people know 'Family Doctor Registration Program' and what is people's real needs about 'Family Doctor Registration Program. We selected l,800 telephone numbers in Seoul, Chongju city, and Ansung-Gun by multi-stage stratified random sampling. Three trained survey personnels called them and got answers to the premade questionnaire until they completed the questionnaires of 200 persons in each community. The calling time was 7-9 p.m. from Monday to Friday, 3-9 p.m. on Saturday, and 9 a.m. to 9 p.m. on Sunday. We dropped out the persons who did not respond 3 times. The subjects consisted of 222 male and 367 female residents. Their ages ranged from 20 to 78: 24.8% in their 30s, 23.4% in their 20s, 22.5% in their 40s in male, and 35.2% in their 30s, 22.5% in their 40s, 18.5% in their 20s in female. 9.9% of male and 13.2% of female had their Family Doctors. The specialties of their Family, Doctors were internists in 56.2%, general surgeons in ll.0%. The persons who did not have their family, doctors were asked which doctors they would prefer if they had choices of family doctor. The results were internists in 50.3%, family physicians in 13.0%, pediatricians in 4.8%. Only 16.0% residents knew that government tried to introduce Family Doctor Registration Program. The 'Family Doctor Registration Program' was not well known to people. The results of our study showed that more effective incentives and public notifications are needed to activate this program.
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Summary
- A case-control study on the effects of the genetic polymorphisms of N-acetyltransferase 2 and glutathione S-transferase mu and theta on the risk of bladder cancer.
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Heon Kim, Wun Jae Kim, Hyung Lae Lee, Moo Song Lee, Cheol Hwan Kim, Ro Sa Kim, Hong Mei Nam
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Korean J Prev Med. 1998;31(2):275-284.
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Abstract
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- Activities of enzymes involved in the metabolism of various carcinogenic xenobiotics is one of the most important host factors for cancer occurrence. N-acetyltransferase (NAT) and glutathione S-transferases (GST) are enzymes which reduce the toxicity of activated carcinogenic metabolites. Slow N-acetylation and lack of GST mu (GSTM1) were reported as risk factors of bladder cancer. GST theta (GSTT1), which is another type of GST, was reported to be deleted at higher proportion among Koreans. Since cause of bladder cancer is not fully explained by single risk factor, many kinds of enzymes would be involved in the metabolism of carcinogens excreted in urine. This study was performed to investigate whether the polymorphisms of NAT2, GSTM1 and GSTT1 are risk factors of bladder cancer and to evaluate the effects of their interaction on bladder cancer development. Sixty-seven bladder cancer and 67 age- and sex-matched non-cancer patients hospitalized in Chungbuk National University Hospital from March to December 1996, are the subjects of this case-control study. Questionnaire interview was done and the genotypes of NAT2, GSTM1 and GSTT1 were identified using PCR methods with DNA extracted from venous blood. The effects of the polymorphism of NAT2 and GSTM1 and their interaction on bladder cancer were statistically tested after controlling the other risk factors. The frequencies of slow, intermediate, and rapid acetylators were 3.0%, 38.8%, and 58.2% for the cases, and 7.6%, 40.9%, and 51.5% for the controls, respectively. The risk of bladder cancer was not associated with the increase of NAT2 activity(x(2) trend=l.18, P-value>0.05). GSTM1 was deleted in 68.7% of the cases and 49.3% of the controls (x(2)=5.21, P-value<0.05), and the odds ratio (95% CI) was 2.23 (l.12 - 4.56). GSTT1 deletion, the rate of which were 26.9% for the bladder cancer patients and 43.3% for the controls, was a significant protective factor against bladder cancer. Smoking history, turned out to be insignificant as a risk factor of bladder cancer (OR=l.85, 95% CI: 0.85 - 4.03), and occupation could not be tested because of the extremely small number of occupational history related to the increase of bladder cancer. In multiple logistic analysis controlling the effects of other risk factors, GSTM1 deletion was the only significant risk factor for bladder cancer (OR: 2.56, 95% CI: l.22-5.36, P-value<0.05), but slow acetylation and GSTT1 deletion were not. These results suggest that GSTM1 deletion may, be a significant risk factor of bladder cancer. Since there have been much debates on causal relationship between slow acetylation and GSTT1 deletion, and bladder cancer, further studies are needed.
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