1Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea.
2Institute of Forensic Medicine, Pusan National University School of Medicine, Busan, Korea.
3Department of Occupational Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Copyright © 2012 The Korean Society for Preventive Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
(n) |
APC |
p16INK4a |
RASSF1A |
Twist1 |
TIMP3 |
E-canherin |
ABCB1 |
COX2 |
Smad4 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | Freq | p-value | |
Age (y) | ||||||||||||||||||
<60 (48) | 21 (43.8) | 0.43 | 6 (12.5) | 0.22 | 6 (12.5) | 0.06 | 29 (60.4) | 0.81 | 23 (47.9) | 0.67 | 9 (18.8) | 0.1 | 36 (75.0) | 0.09 | 21 (43.8) | 0.69 | 17 (35.4) | 0.96 |
≥60 (52) | 31 (59.6) | 8 (15.4) | 14 (26.9) | 29 (55.8) | 20 (38.5) | 19 (36.5) | 33 (63.5) | 30 (57.7) | 22 (42.3) | |||||||||
Gender | ||||||||||||||||||
Male (51) | 29 (56.9) | 0.08 | 6 (11.8) | 0.68 | 13 (25.5) | 0.19 | 29 (56.9) | 0.64 | 23 (45.1) | 0.34 | 18 (35.3) | 0.05 | 39 (76.5) | 0.08 | 27 (52.9) | 0.16 | 20 (39.2) | 0.48 |
Female (49) | 23 (46.9) | 8 (16.3) | 7 (14.3) | 29 (59.2) | 20 (40.8) | 10 (20.4) | 30 (61.2) | 24 (49.0) | 19 (38.8) | |||||||||
Smoking | ||||||||||||||||||
Ever (20) | 12 (60.0) | 0.48 | 2 (10.0) | 0.291 | 3 (15.0) | 0.541 | 15 (75.0) | 0.09 | 6 (30.0) | 0.19 | 8 (40.0) | 0.18 | 15 (75.0) | 0.66 | 8 (40.0) | 0.27 | 7 (35.0) | 0.68 |
Never (80) | 40 (50.0) | 12 (15.0) | 17 (21.3) | 43 (53.8) | 37 (46.3) | 20 (25.0) | 54 (67.5) | 43 (53.8) | 32 (40.0) | |||||||||
Alcohol | ||||||||||||||||||
Yes (21) | 12 (57.1) | 0.67 | 4 (19.0) | 1.001 | 4 (19.0) | 0.761 | 13 (61.9) | 0.68 | 7 (33.3) | 0.31 | 8 (38.1) | 0.25 | 17 (81.0) | 0.09 | 11 (52.4) | 0.89 | 9 (42.9) | 0.68 |
No (79) | 40 (50.6) | 10 (12.7) | 16 (20.3) | 45 (57.0) | 36 (45.6) | 20 (25.3) | 52 (65.8) | 40 (50.6) | 30 (38.0) | |||||||||
Staging | ||||||||||||||||||
I (3) | 2 (66.7) | 0.781 | 0.541 | 1 (33.3) | 0.711 | 1 (33.3) | 0.351 | 1 (33.3) | 0.721 | 2 (66.7) | 0.061 | 2 (66.7) | 0.30* | 1 (33.3) | 0.211 | 1 (33.3) | 0.981 | |
II (49) | 26 (53.1) | 8 (16.3) | 10 (20.4) | 31 (63.3) | 24 (49.0) | 18 (36.7) | 36 (73.5) | 30 (61.2) | 20 (40.8) | |||||||||
III (40) | 21 (52.5) | 4 (10.0) | 8 (20.0) | 20 (50.0) | 15 (37.5) | 7 (17.5) | 27 (67.5) | 16 (40.0) | 15 (37.5) | |||||||||
IV (8) | 3 (37.5) | 2 (25.0) | 1 (12.5) | 6 (75.0) | 3 (37.5) | 1 (12.5) | 4 (50.0) | 4 (50.0) | 3 (37.5) |
Gene type | APC | p16INK4a | RASSF1A | Twist1 | TIMP3 | E-cadherin | ABCB1 | COX2 |
---|---|---|---|---|---|---|---|---|
p16INK4a | - 0.02 | |||||||
RASSF1A | 0.05 | 0.01 | ||||||
Twist1 | 0.17 | - 0.01 | 0.02 | |||||
TIMP3 | 0.25 | 0.22 | 0.02 | 0.16 | ||||
E-cadherin | 0.32 | 0.06 | 0.511 | 0.18 | 0.21 | |||
ABCB1 | 0.14 | 0.00 | 0.09 | 0.38 | 0.24 | 0.27 | ||
COX2 | 0.20 | 0.11 | - 0.05 | 0.26 | 0.32 | 0.19 | 0.36 | |
Smad4 | 0.33 | 0.03 | - 0.04 | 0.33 | 0.26 | 0.23 | 0.421 | 0.521 |
KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway