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Throat carriage rate and antimicrobial resistance of Streptococcus pyogenes in rural children
Gast처n Delpech1, Monica Sparo2 , Beatriz Baldaccini2, Gisela Pourcel1, Sabina Lissarrague2, Leonardo Garc챠a Allende3
1School of Medicine, Universidad Nacional del Centro de la Provincia de Buenos Aires, Olavarria, Argentina
2Hospital Ramon Santamarina, Tandil, Argentina
3Center of Biochemical Studies, Tandil, Argentina
Corresponding Author: Monica Sparo ,Tel: +54-2494-422011, Fax: +54-2494-42-8797, Email: monicasparo@gmail.com
Received: December 17, 2015;  Accepted: December 18, 2016.
ABSTRACT
Objectives:
Determine the prevalence of asymptomatic carriers of GAS in children from a rural community and investigate the association between episodes of acute pharyngitis and carrier status.
Method:
observational, prospective and transversal study. Throat swabs were collected from September to November 2013 among 5-13 years old children from a rural community (Maria Ignacia-Vela, Argentina). Phenotypical characterization of isolates was performed by conventional tests. Antimicrobial susceptibility was assayed for penicillin, tetracycline, chloramphenicol, erythromycin and clindamycin (disk diffusion) Minimum Inhibitory Concentration was determined for penicillin, cefotaxime, tetracycline and erythromycin.
Results:
Carriage of 棺-hemolytic streptococci has been detected (18.1%): Streptococcus pyogenes (n: 18) followed by S. dysgalactiae ssp. equisimilis (n: 5). Highest percentage of GAS was found in 8-10 years old children. No significant association between the number of episodes of acute pharyngitis suffered in the last year and the carrier state was detected (p>0.05). Tetracycline resistance (55.5%) and macrolides resistant phenotypes (11.1%) were observed. Penicillin, cefotaxime and chloramphenicol resistance was not expressed in any streptococcal isolate.
Conclusions:
The present study has proven a significant throat carriage of GAS and the presence of Group C streptococci (S. dysgalactiae ssp. equisimilis) in an Argentinian rural population. These results point out the need of a continuous surveillance of GAS and non-GAS carriage as well as the antimicrobial resistance in a highly susceptible population, such as school aged rural children. An extended surveillance program including school aged children from different cities should be considered to estimate the situation in Argentina.
Key words: Streptococcus pyogenes; carriage; antimicrobials; resistance; children; rural
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