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J Prev Med Public Health > Volume 40(2); 2007 > Article
Journal of Preventive Medicine and Public Health 2007;40(2): 108-113. doi: http://dx.doi.org/10.3961/jpmph.2007.40.2.108
Statistical Issues in Genomic Cohort Studies.
Sohee Park
Cancer Biostatistics Branch, Division of Cancer Registration and Epidemiology, National Cancer Center, Korea. shpark@ncc.re.kr
ABSTRACT
When conducting large-scale cohort studies, numerous statistical issues arise from the range of study design, data collection, data analysis and interpretation. In genomic cohort studies, these statistical problems become more complicated, which need to be carefully dealt with. Rapid technical advances in genomic studies produce enormous amount of data to be analyzed and traditional statistical methods are no longer sufficient to handle these data. In this paper, we reviewed several important statistical issues that occur frequently in large-scale genomic cohort studies, including measurement error and its relevant correction methods, cost-efficient design strategy for main cohort and validation studies, inflated Type I error, gene-gene and gene-environment interaction and time-varying hazard ratios. It is very important to employ appropriate statistical methods in order to make the best use of valuable cohort data and produce valid and reliable study results.
Key words: Cohort studies; Epidemiologic methods; Validation studies; Research design; Measurement error; Gene-environment interaction; Proportional hazards models
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