Journal of Preventive Medicine and Public Health

Original Articles

Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-sectional Study: Dongui Hong, Jin-Young Min, Kyoung-Bok Min; J Prev Med Public Health. 2021;54(6):471-480. Published online November 30, 2021; DOI: https://doi.org/10.3961/jpmph.21.435

3,938 View
147 Download
21 Web of Science
21 Crossref

Abstract Summary PDF Supplementary Material

Objectives
Cadmium is widely used, leading to extensive environmental and occupational exposure. Unlike other organs, for which the harmful and carcinogenic effects of cadmium have been established, the hepatotoxicity of cadmium remains unclear. Some studies detected correlations between cadmium exposure and hepatotoxicity, but others concluded that they were not associated. Thus, we investigated the relationship between cadmium and liver damage in the general population.
Methods
In total, 11 838 adult participants from National Health and Nutrition Examination Survey 1999-2015 were included. Urinary cadmium levels and the following liver function parameters were measured: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), total bilirubin (TB), and alkaline phosphatase (ALP). Linear and logistic regression analyses were performed to assess the associations between urinary cadmium concentrations and each liver function parameter after adjusting for age, sex, race/ethnicity, annual family income, smoking status, alcohol consumption status, physical activity, and body mass index.
Results
The covariate-adjusted results of the linear regression analyses showed significant positive relationships between log-transformed urinary cadmium levels and each log-transformed liver function parameter, where beta±standard error of ALT, AST, GGT, TB, and ALP were 0.049±0.008 (p<0.001), 0.030±0.006 (p<0.001), 0.093±0.011 (p<0.001), 0.034±0.009 (p<0.001), and 0.040±0.005 (p<0.001), respectively. Logistic regression also revealed statistically significant results. The odds ratios (95% confidence intervals) of elevated ALT, AST, GGT, TB, and ALP per unit increase in log-transformed urinary cadmium concentration were 1.360 (1.210 to 1.528), 1.307 (1.149 to 1.486), 1.520 (1.357 to 1.704), 1.201 (1.003 to 1.438), and 1.568 (1.277 to 1.926), respectively.
Conclusions
Chronic exposure to cadmium showed positive associations with liver damage.

Summary

Korean summary
카드뮴은 사회 전반에서 널리 쓰이고 있어 직업적인 노출은 물론 환경적인 노출이 빈번히 일어나고 있다. 본 연구는 미국 국민건강영양조사 데이터를 이용하였으며 소변 내 카드뮴의 증가는 알라닌 아미노전이효소 (ALT), 아스파테이트 아미노전이효소 (AST), 감마 글루타밀전이효소 (GGT), 총 빌리루빈, 알칼리 인산분해효소 (ALP)의 상승과 관련이 있었다. 따라서 만성적인 카드뮴 노출은 간 손상과 연관이 있다고 할 수 있다.

Citations

Citations to this article as recorded by

Cadmium-associated protein changes in residents of contaminated areas: Abandoned mine and smelter
Sora Mun, You-Rim Lee, Jiyeong Lee, Seungyeon Lee, Yeeun Yun, Jeeyoung Kim, Jung-Yeon Kwon, Woo Jin Kim, Yong Min Cho, Young-Seoub Hong, Hee-Gyoo Kang
Environmental Pollution.2024; 345: 123512. CrossRef
Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium
Aleksandar Cirovic, Soisungwan Satarug
International Journal of Molecular Sciences.2024; 25(3): 1851. CrossRef
Cross-talk between Vimentin and autophagy regulates blood-testis barrier disruption induced by cadmium
Na Chen, Xiaoyan Wan, Mei Wang, Yamin Li, Xiaofei Wang, Ling Zeng, Jinzhao Zhou, Yanwei Zhang, Shun Cheng, Yi Shen
Environmental Pollution.2024; 346: 123625. CrossRef
Correlation between urinary rare earth elements and liver function in a Zhuang population aged 35–74 years in Nanning
Xingxi Luo, Liling Wei, Shun Liu, Kaili Wu, Dongping Huang, Suyang Xiao, Erna Guo, Lei Lei, Xiaoqiang Qiu, Xiaoyun Zeng
Journal of Trace Elements in Medicine and Biology.2024; 84: 127426. CrossRef
Changes in Endogenous Essential Metal Homeostasis in the Liver and Kidneys during a Six-Month Follow-Up Period after Subchronic Cadmium Exposure
Rafał Kusak, Marzenna Nasiadek, Joanna Stragierowicz, Wojciech Hanke, Anna Kilanowicz
International Journal of Molecular Sciences.2024; 25(7): 3829. CrossRef
The Effect of Smoking Habits on Blood Cadmium and Lead Levels in Residents Living Near a Mining and Smelting Area in Northwest China: a Cross-Sectional Study
Hui Dai, Honglong Zhang, Haiping Wang, Jingping Niu, Bin Luo, Jun Yan, Xun Li
Biological Trace Element Research.2023; 201(3): 1101. CrossRef
Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations
Mazyar Yazdani, Sonia Distante, Lars Mørkrid, Rune J. Ulvik, Bjørn J. Bolann
Biological Trace Element Research.2023; 201(7): 3193. CrossRef
Associations of blood metals with liver function: Analysis of NHANES from 2011 to 2018
Wenjie Li, Xinyan Li, Jing Su, Han Chen, Ping Zhao, Haisheng Qian, Xin Gao, Qiang Ye, Guoxin Zhang, Xuan Li
Chemosphere.2023; 317: 137854. CrossRef
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium
Cong Liu, Hui‐Juan Li, Wei‐Xia Duan, Yu Duan, Qin Yu, Tian Zhang, Ya‐Pei Sun, Yuan‐Yuan Li, Yong‐Sheng Liu, Shang‐Cheng Xu
Advanced Science.2023;[Epub] CrossRef
Effects of Environmental Cadmium Exposure on the Liver in Korean Adults: Cross-Sectional and Longitudinal Studies
Mi-Na Seo, Sang-Yong Eom, Ji-Ae Lim, Jung-Eum Lee, Byung-Sun Choi, Ho-Jang Kwon, Young-Seoub Hong, Heon Kim, Jung-Duck Park
Archives of Environmental Contamination and Toxicology.2023; 84(2): 237. CrossRef
Estimation of health risks associated with dietary cadmium exposure
Soisungwan Satarug, David A. Vesey, Glenda C. Gobe, Kenneth R. Phelps
Archives of Toxicology.2023; 97(2): 329. CrossRef
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
Arianna Dolce, Sara Della Torre
Nutrients.2023; 15(10): 2335. CrossRef
ROS‐mediated PERK‐CHOP pathway plays an important role in cadmium‐induced HepG2 cells apoptosis
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Environmental Toxicology.2023; 38(9): 2271. CrossRef
Association between mixed urinary metal exposure and liver function: analysis of NHANES data
Bowen Zha, Huanchang Xu, Yuqi Liu, Xiaqin Zha
Environmental Science and Pollution Research.2023; 30(52): 112564. CrossRef
Association of urinary bisphenols with oxidative stress and inflammatory markers and their role in obesity
Ren Zhou, Lei Zhang, Yu Sun, Jia Yan, Hong Jiang
Ecotoxicology and Environmental Safety.2023; 266: 115546. CrossRef
Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?
Soisungwan Satarug
Cells.2023; 13(1): 83. CrossRef
Gut microbiota–bile acid–intestinal Farnesoid X receptor signaling axis orchestrates cadmium-induced liver injury
Yunhuan Liu, Weili Kang, Shuiping Liu, Jinyan Li, Jinyan Liu, Xingxiang Chen, Fang Gan, Kehe Huang
Science of The Total Environment.2022; 849: 157861. CrossRef
Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium
Soisungwan Satarug, Glenda C. Gobe, David A. Vesey
Toxics.2022; 10(8): 472. CrossRef
The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure
Zhi Chen, Qinyue Lu, Jiacheng Wang, Xiang Cao, Kun Wang, Yuhao Wang, Yanni Wu, Zhangping Yang
Frontiers in Immunology.2022;[Epub] CrossRef
Mitigation of Cadmium Toxicity through Modulation of the Frontline Cellular Stress Response
Soisungwan Satarug, David A. Vesey, Glenda C. Gobe
Stresses.2022; 2(3): 355. CrossRef
Oligochaeta ramosa (Roxb.) Extract Regulates Lipid Metabolism and Exerts Hepatoprotective Effects in Cadmium-Induced Hepatic Injury in Rats
Saira Aslam, Fiaz-ud-Din Ahmad, Waseem Hassan, Manal Ali Buabeid, Imran Mukhtar, Muhammad Ihtisham Umar, Nihal Abdallah Ibrahim, Daniel Dias Rufino Arcanjo
Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef

Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study: Jonghyuk Choi, Sanghyuk Bae, Hyungryul Lim, Ji-Ae Lim, Yong-Han Lee, Mina Ha, Ho-Jang Kwon; J Prev Med Public Health. 2017;50(6):377-385. Published online November 7, 2017; DOI: https://doi.org/10.3961/jpmph.17.099

23,990 View
222 Download
23 Crossref

Abstract PDF Supplementary Material

Objectives
Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT).
Methods
We repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly.
Results
GGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking.
Conclusions
Hg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption.

Summary

Citations

Citations to this article as recorded by

Selenium and zinc alleviate hepatotoxicity induced by heavy metal mixture (cadmium, mercury, lead and arsenic) via attenuation of inflammo‐oxidant pathways
Harrison Ozoani, Anthonet N. Ezejiofor, Kenneth O. Okolo, Chinna N. Orish, Ana Cirovic, Aleksandar Cirovic, Orish E. Orisakwe
Environmental Toxicology.2024; 39(1): 156. CrossRef
Deleterious effects of mercury contamination on immunocompetence, liver function and egg volume in an antarctic seabird
Andrés E. Ibañez, William F. Mills, Paco Bustamante, Lara M. Morales, Diego S. Torres, Beatriz D' Astek, Rocío Mariano-Jelicich, Richard A. Phillips, Diego Montalti
Chemosphere.2024; 346: 140630. CrossRef
Letter to the editor: In utero exposure to mercury is associated with increased susceptibility to liver injury and inflammation in childhood
Muhammad Zawar Asif, Muhammad Umair, Muhammad Shehryar
Hepatology.2023; 77(2): E38. CrossRef
Associations of blood metals with liver function: Analysis of NHANES from 2011 to 2018
Wenjie Li, Xinyan Li, Jing Su, Han Chen, Ping Zhao, Haisheng Qian, Xin Gao, Qiang Ye, Guoxin Zhang, Xuan Li
Chemosphere.2023; 317: 137854. CrossRef
Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
International Journal of Environmental Research and Public Health.2023; 20(4): 3290. CrossRef
Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018–2022
Youngchan Chi, Jong-Tae Park, Sewhan Na, Kyeongmin Kwak
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef
Dissecting the role of cadmium, lead, arsenic, and mercury in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Environmental Research.2023; 238: 117134. CrossRef
Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
Environmental Research.2022; 204: 111888. CrossRef
Identification source and human health risk assessment of potentially toxic metal in soil samples around karst watershed of Pangkajene, Indonesia
Anwar Mallongi, Ratna Dwi Puji Astuti, Ridwan Amiruddin, Muhammad Hatta, Annisa Utami Rauf
Environmental Nanotechnology, Monitoring & Management.2022; 17: 100634. CrossRef
Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China
Jun Yan, Honglong Zhang, Jingping Niu, Bin Luo, Haiping Wang, Meng Tian, Xun Li
Environmental Geochemistry and Health.2022; 44(11): 4173. CrossRef
A novel nano-palladium embedded on the mesoporous silica nanoparticles for mercury vapor removal from air by the gas field separation consolidation process
Hamid Shirkhanloo, Farideh Golbabaei, Amir Vahid, Ali Faghihi Zarandi
Applied Nanoscience.2022; 12(5): 1667. CrossRef
Associations between lead, cadmium, mercury, and arsenic exposure and alanine aminotransferase elevation in the general adult population: an exposure–response analysis
Xiaoming Zhou, Yijun Feng, Zonglin Gong
Environmental Science and Pollution Research.2022; 29(35): 53633. CrossRef
Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases
Hai Duc Nguyen, Min-Sun Kim
Environmental Pollution.2022; 309: 119780. CrossRef
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic
Mahdi Balali-Mood, Kobra Naseri, Zoya Tahergorabi, Mohammad Reza Khazdair, Mahmood Sadeghi
Frontiers in Pharmacology.2021;[Epub] CrossRef
Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014
Yun-Jung Yang, Eun-Jung Yang, Kyongjin Park, Subin Oh, Taehyen Kim, Yeon-Pyo Hong
International Journal of Environmental Research and Public Health.2021; 18(12): 6412. CrossRef
In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood
Nikos Stratakis, Lucy Golden‐Mason, Katerina Margetaki, Yinqi Zhao, Damaskini Valvi, Erika Garcia, Léa Maitre, Sandra Andrusaityte, Xavier Basagana, Eva Borràs, Mariona Bustamante, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Line Småstuen Haug,
Hepatology.2021; 74(3): 1546. CrossRef
The Relationship Between Embryotoxicity and Oxidative Stress Produced by Aluminum, Iron, Mercury, and Their Mixture on Cyprinus carpio
Selene Cano-Viveros, Marcela Galar-Martínez, Eloy Gasca-Pérez, Sandra García-Medina, Karina Ruiz-Lara, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores
Water, Air, & Soil Pollution.2021;[Epub] CrossRef
Tissue distribution of mercury and copper after Aarogyavardhini Vati treatment in rat model of CCl4 induced chronic hepatotoxicity
Shrirang Jamadagni, Pallavi Jamadagni, Binita Angom, Dhirendranath Mondal, Sachchidanand Upadhyay, Sudesh Gaidhani, Jayram Hazra
Journal of Ayurveda and Integrative Medicine.2020; 11(4): 508. CrossRef
Mercury exposure and premature mortality in the Grassy Narrows First Nation community: a retrospective longitudinal study
Aline Philibert, Myriam Fillion, Donna Mergler
The Lancet Planetary Health.2020; 4(4): e141. CrossRef
The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Journal of Trace Elements in Medicine and Biology.2020; 62: 126601. CrossRef
Blood mercury and liver enzymes: A pan-India retrospective correlation study
Krishnakumar Sivapandi, Amruta Velumani, Kallathikumar Kallathiyan, Sandhya Iyer, Prachi Sinkar
Toxicology and Industrial Health.2020; 36(12): 1019. CrossRef
Mercury in cetaceans: Exposure, bioaccumulation and toxicity
Joanna L. Kershaw, Ailsa J. Hall
Science of The Total Environment.2019; 694: 133683. CrossRef
Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents
Runsen Chen, Yang Xu, Cheng Xu, Yaqin Shu, Siyu Ma, Changgui Lu, Xuming Mo
Environmental Science and Pollution Research.2019; 26(30): 31384. CrossRef

Analysis of the Change of Health Status Among the Republic of Korea Air Force Soldiers During Military Service: Seok-Ju Yoo, Won-Ju Park, Kwan Lee, Hyun-Sul Lim, Hyun-Jin Kim, Suk-Ho Lee; J Prev Med Public Health. 2014;47(4):230-235. Published online July 31, 2014; DOI: https://doi.org/10.3961/jpmph.2014.47.4.230

8,399 View
75 Download
2 Crossref

Abstract PDF

Objectives
The aim of this study was to investigate whether the health status of Republic of Korea Air Force (ROKAF) soldiers changed after one year of military service. Methods: We selected 483 ROKAF soldiers from the 11 749 recruits who participated in the 2011 physical examination. The selected soldiers underwent another physical examination in 2012 for advancement to senior airman. Data from 2011 and 2012 were merged. To collect data on lifestyle, a questionnaire was sent to all included subjects via the military intranet e-mail service. Results: The percentage of recruits with an abnormal alanine transaminase level (normal range <40 IU/L) decreased from recruitment (13.7%) to the following year (2.7%). Moreover, the percentage of obese soldiers (body mass index ≥25 kg/m2) decreased from recruitment (20.5%) to the following year (10.4%). There was a significant change in mean duration of exercise carried out each day before (0.8±1.3 hours) and after (1.0±0.7 hours) joining the ROKAF service. Conclusions: These ROKAF soldiers were generally in good health before and after joining the armed service. After one year of military service, the health status of most soldiers improved, especially with respect to body mass index and alanine transaminase level.

Summary

Citations

Citations to this article as recorded by

Behavioral impact of national health campaigns on healthy lifestyle practices among young adults in Singapore: a cross-sectional study
Yong Zhi Khow, Talia Li Yin Lim, Jarret Shoon Phing Ng, Jiaxuan Wu, Chuen Seng Tan, Kee Seng Chia, Nan Luo, Wei Jie Seow
BMC Public Health.2021;[Epub] CrossRef
Strategic Priorities to Improve Effectiveness of Anti-smoking Interventions for the Korean Military: An Application of the Analytic Hierarchy Process
Yun-Kyoung Song, Jae Hyun Kim, Boyoon Choi, Nayoung Han, Myeong Gyu Kim, Jeongsam Lee, Handuk Lee, Jieun Yoon, Beom-Jin Lee, Jung Mi Oh
Military Medicine.2018; 183(7-8): e223. CrossRef

First
Prev
Page of 1
Next
Last

Search